ArticleMaterials today. Bio2025
The injectable cationic double-crosslinked hydrogel facilitates bone regeneration and repair through sustained antibacterial activity.
Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- A biomimetic core-shell nanofibrous dressing for temporally coordinated infection control and mitochondrial protection in diabetic wounds.Materials today. Bio · 2026Article
- Glycosaminoglycans in tissue regeneration: Insights into glycobiology and their biomedical application.Bioactive materials · 2026Review
- 3D printed HAMA/GelMA/lignosulfonate hydrogel integrating oxygen-releasing and antioxidative modules for liver regeneration.Journal of nanobiotechnology · 2026Article
- Emerging potential of engineered nanozymes in periodontitis treatment: from monotherapy to hierarchical therapy.Journal of nanobiotechnology · 2026Review
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to the barrier effect of dental plaque and the growing issue of antibiotic resistance, the efficacy of conventional antimicrobial agents against oral pathogens has progressively declined. Chronic periodontal infections are recalcitrant to eradication and exert inhibitory effects on bone repair and regeneration, representing one of the primary challenges in the management of periodontitis-induced bone defects. In this study, we developed an injectable cationic photopolymerizable dual-crosslinked O-HAMA/GelMA/PLL hydrogel. The aldehyde groups on oxidized HAMA undergo a Schiff base reaction with the amino groups of ε-polylysine (ε-PLL), forming dynamic crosslinks. Subsequently, blue light triggers a radical polymerization of the double bonds present in GelMA and O-HAMA, creating a secondary layer of covalent crosslinks. This dual-crosslinked structure enables the sustained release of the cationic antimicrobial peptide ε-PLL for up to 14 days, demonstrating superior controlled-release properties. Furthermore, the hydrogel exhibits excellent biocompatibility and enhanced mechanical strength, thus fulfilling the requirements for clinical applications. The
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