Evidence map›Paper›PMID 41281650›Full record

ArticleMaterials today. Bio2025

CD24-targeted cystine and glucose oxidase cascade catalytic nanosystem triggers disulfidptosis in neuroblastoma.

Tao Mi, Junhong Liu, Junyi Luo, Xiangpan Kong, XiaoJun Tan, Liming Jin, Peng Guo, Dawei He

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
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  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tao MiDepartment of Urology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Children Urogenital Development and Tissue Engineering of Chongqing Education Commission of China, The Laboratory of Targeted Delivery of Traditional Chinese Medicine, China.
Junhong LiuDepartment of Urology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Children Urogenital Development and Tissue Engineering of Chongqing Education Commission of China, The Laboratory of Targeted Delivery of Traditional Chinese Medicine, China.
Junyi LuoDepartment of Urology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Children Urogenital Development and Tissue Engineering of Chongqing Education Commission of China, The Laboratory of Targeted Delivery of Traditional Chinese Medicine, China.
Xiangpan KongDepartment of Urology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Children Urogenital Development and Tissue Engineering of Chongqing Education Commission of China, The Laboratory of Targeted Delivery of Traditional Chinese Medicine, China.
XiaoJun TanDepartment of Urology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Children Urogenital Development and Tissue Engineering of Chongqing Education Commission of China, The Laboratory of Targeted Delivery of Traditional Chinese Medicine, China.
Liming JinDepartment of Urology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Children Urogenital Development and Tissue Engineering of Chongqing Education Commission of China, The Laboratory of Targeted Delivery of Traditional Chinese Medicine, China.
Peng GuoDepartment of Urology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Children Urogenital Development and Tissue Engineering of Chongqing Education Commission of China, The Laboratory of Targeted Delivery of Traditional Chinese Medicine, China.
Dawei HeDepartment of Urology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Children Urogenital Development and Tissue Engineering of Chongqing Education Commission of China, The Laboratory of Targeted Delivery of Traditional Chinese Medicine, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroblastoma remains a challenging pediatric malignancy with limited therapeutic options, often complicated by chemoresistance and severe systemic toxicity. In this study, we developed a CD24-targeted nanodrug delivery platform that co-delivers cystine and glucose oxidase (GOx) to induce disulfidptosis in neuroblastoma cells. We engineered exosome-mimetic vesicles (EM-CD24) by transfecting HEK-293T cells with a plasmid encoding an anti-CD24 nanobody fused to a glycosylphosphatidylinositol (GPI) anchor signal derived from decay-accelerating factor (DAF), followed by sequential extrusion to obtain EMs with native exosome-like properties and scalable production potential. These vesicles display surface anti-CD24 nanobodies, enabling tumor-specific targeting. Our findings revealed that while cystine promotes cell growth under normal conditions, it induces disulfidptosis under glucose-deprived conditions. Leveraging this metabolic duality, we developed a redox-responsive nanoplatform, Cys-hMnO

Indexed as

CD24CystineDisulfidptosisGlucose oxidaseNeuroblastoma

Identifiers

PMID41281650
PMCPMC12639498

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.