Evidence map›Paper›PMID 41281645›Full record

ArticleMaterials today. Bio2025

Ultra-small coordination dihydromyricetin nanodots attenuate alveolar bone resorption in periodontitis through inhibition of ITGB3-Driven osteoclast differentiation.

Bin Zhao, Shuqi Sun, Yicheng Hao, Qirong Wu, Yang Yang, Xinjie Qiu, Jingyi Yang, Yan Zhang, Gege Li, Dongning He and 1 more

Abstract read
PubMed Full text at PMC Publisher
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Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bin ZhaoShanxi Medical University School and Hospital of Stomatology, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, 030001, China.
Shuqi SunShanxi Medical University School and Hospital of Stomatology, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, 030001, China.
Yicheng HaoShanxi Medical University School and Hospital of Stomatology, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, 030001, China.
Qirong WuShanxi Medical University School and Hospital of Stomatology, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, 030001, China.
Yang YangShanxi Medical University School and Hospital of Stomatology, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, 030001, China.
Xinjie QiuShanxi Medical University School and Hospital of Stomatology, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, 030001, China.
Jingyi YangShanxi Medical University School and Hospital of Stomatology, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, 030001, China.
Yan ZhangShanxi Medical University School and Hospital of Stomatology, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, 030001, China.
Gege LiShanxi Medical University School and Hospital of Stomatology, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, 030001, China.
Dongning HeShanxi Medical University School and Hospital of Stomatology, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, 030001, China.
Feiyan YuShanxi Medical University School and Hospital of Stomatology, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, 030001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Irreversible alveolar bone resorption induced by periodontitis constitutes a major etiological factor in adult tooth loss, with its underlying pathological mechanism tightly linked to dysregulated osteoclast differentiation. Conventional clinical interventions for alveolar bone resorption, such as basic periodontal therapy and surgical procedures, are limited in their capacity to effectively inhibit osteoclast differentiation. Dihydromyricetin (DMY), a naturally derived flavonoid compound, exhibits promising inhibitory activity against osteoclast differentiation; however, its poor aqueous solubility and suboptimal bioavailability following localized administration hinder its therapeutic potential. To address these limitations, this study developed ultra-small coordination nanodots (DMY-NDs) with diameters under 10 nm through the coordination of DMY with copper ions and polyvinylpyrrolidone (PVP), thereby markedly improving its solubility and drug delivery efficiency.

Indexed as

Alveolar bone resorptionDihydromyricetinITGB3Osteoclast differentiationUltra-small coordination nanodots

Identifiers

PMID41281645
PMCPMC12639494

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.