Evidence map›Paper›PMID 41281642›Full record

ArticleMaterials today. Bio2025

Multilayered structure on titanium implants promotes diabetic osseointegration through synergetic regulation of oxidative balance and immune homeostasis in microenvironment.

Yao Xiao, Gaoyang Wang, Maowen Chen, Huan Yang, Xiaohong Zhang, Zhongxue Wang, Qian Chen, Zihui Xia, Liangliang Dai, Chenghu Hu and 1 more

Abstract read
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. A mechanically compliant SrTiOMaterials today. Bio · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yao XiaoXi'an Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Research, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an, Shaanx, 710072, PR China.
Gaoyang WangXi'an Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Research, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an, Shaanx, 710072, PR China.
Maowen ChenSchool of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, 81 Meishan Road, Hefei, Anhui, 230012, PR China.
Huan YangXi'an Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Research, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an, Shaanx, 710072, PR China.
Xiaohong ZhangXi'an Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Research, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an, Shaanx, 710072, PR China.
Zhongxue WangXi'an Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Research, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an, Shaanx, 710072, PR China.
Qian ChenXi'an Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Research, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an, Shaanx, 710072, PR China.
Zihui XiaXi'an Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Research, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an, Shaanx, 710072, PR China.
Liangliang DaiXi'an Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Research, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an, Shaanx, 710072, PR China.
Chenghu HuXi'an Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Research, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an, Shaanx, 710072, PR China.
Zhang YuanXi'an Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Research, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an, Shaanx, 710072, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia and chronic inflammation, which is considered a relative contraindication for implantation in clinical practice. In the pathological microenvironment of DM, the endless vicious cycle of oxidative stress-immune disorder-chronic inflammation severely inhibits new bone formation, causing the stagnant healing and poor osseointegration. Herein, we design a multilayered structure composing of 18β-glycyrrhetinic acid modified chitosan (CS-GA) and gelatin (Gel) embedded with trimanganese tetroxide nanozymes (Mn

Indexed as

Anti-oxidative stressImmunomodulationMacrophagesOsseointegrationSurface modification

Identifiers

PMID41281642
PMCPMC12637064

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.