Evidence map›Paper›PMID 41281604›Full record

ArticleGenes & diseases2026

Intense light mitigates hypoxia-induced right ventricular remodeling and dysfunction through reducing inflammation associated with PF4

Dingyuan Tian, Yingzi Pan, Xiaoyue Lai, Xinyu Bao, Pan Zheng, Yan Tan, Chun Liu, Ziyang Wang, Qingyuan Yang, Yang Liu and 3 more

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Article in Genes & diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Dingyuan TianDepartment of Pathophysiology, College of High Altitude Military Medicine, Army Medical University, Chongqing 400038, China.
Yingzi PanDepartment of Pathophysiology, College of High Altitude Military Medicine, Army Medical University, Chongqing 400038, China.
Xiaoyue LaiDepartment of Pathophysiology, College of High Altitude Military Medicine, Army Medical University, Chongqing 400038, China.
Xinyu BaoDepartment of Cardiovascular Medicine, Laboratory of Chronobiology and Cardiometabolic Disease, Southwest Hospital, Army Medical University, Chongqing 400038, China.
Pan ZhengDepartment of Cardiovascular Medicine, Laboratory of Chronobiology and Cardiometabolic Disease, Southwest Hospital, Army Medical University, Chongqing 400038, China.
Yan TanDepartment of Pathophysiology, College of High Altitude Military Medicine, Army Medical University, Chongqing 400038, China.
Chun LiuDepartment of Cardiovascular Medicine, Laboratory of Chronobiology and Cardiometabolic Disease, Southwest Hospital, Army Medical University, Chongqing 400038, China.
Ziyang WangDepartment of Cardiovascular Medicine, Laboratory of Chronobiology and Cardiometabolic Disease, Southwest Hospital, Army Medical University, Chongqing 400038, China.
Qingyuan YangDepartment of Cardiovascular Medicine, Laboratory of Chronobiology and Cardiometabolic Disease, Southwest Hospital, Army Medical University, Chongqing 400038, China.
Yang LiuDepartment of Pathophysiology, College of High Altitude Military Medicine, Army Medical University, Chongqing 400038, China.
Xiaoqin WanDepartment of Cardiovascular Medicine, Laboratory of Chronobiology and Cardiometabolic Disease, Southwest Hospital, Army Medical University, Chongqing 400038, China.
Zhihui ZhangDepartment of Cardiovascular Medicine, Laboratory of Chronobiology and Cardiometabolic Disease, Southwest Hospital, Army Medical University, Chongqing 400038, China.
Fang DengDepartment of Pathophysiology, College of High Altitude Military Medicine, Army Medical University, Chongqing 400038, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypoxia-induced right ventricular (RV) remodeling and dysfunction present a significant health risk to populations experiencing prolonged hypoxic conditions. Intense light, a noninvasive and easily implemented intervention, has previously been reported to exert cardioprotective effects by improving myocardial ischemia. However, whether intense light provides protective benefits against RV remodeling and the underlying mechanisms remain largely unexplored. In this study, we established mouse models exhibiting RV remodeling and dysfunction through long-term hypoxia to investigate the protective effects of intense light. Echocardiography, hemodynamic parameters measurements, and Fulton index assessments were employed to evaluate RV dysfunction and remodeling. Additionally, single-nuclei RNA sequencing, immunohistochemistry, immunofluorescence, and western blotting analyses were conducted to identify targeted genes in macrophage-associated inflammation within the heart. The results indicate that intense light significantly alleviates hypoxia-induced RV remodeling and dysfunction in mice. Intense light may mediate macrophage-associated inflammation through differentially expressed genes, including PF4, as well as the quantity of macrophages in the right ventricles (RVes). Resident macrophages (Res_Macro) demonstrate cardioprotective effects when intense light is applied, which mitigates RV remodeling. Our findings also suggest that PF4 expression and the presence of PF4

Indexed as

HypoxiaIntense lightMacrophagesPF4Right ventricular remodeling

Identifiers

PMID41281604
PMCPMC12639265

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.