SynthesisCanadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR2025
Conservative versus liberal oxygen therapy in mechanically ventilated patients: A systematic review with meta-analysis.
Synthesis in Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Background: Clinical trials comparing liberal versus conservative oxygen therapy strategies in patients requiring mechanical ventilation have shown contradictory results regarding the best strategy for improving mortality outcomes, length of stay, and ventilator-free days. To summarize the evidence regarding the effects of conservative oxygen therapy compared with liberal oxygen therapy in adult patients admitted to an intensive care unit (ICU). Methods: This systematic review with meta-analysis included controlled and randomized clinical trials obtained from the MEDLINE/PubMed, Embase, the Cochrane Library, Lilacs/bvs, PEDro and ScienceDirect. The effect estimate for mortality was expressed as the relative risk ( Results: Nineteen randomized clinical trials involving more than 10,000 patients were included. Liberal oxygen therapy did not significantly differ from conventional oxygen therapy in terms of mortality ( Conclusion: The findings of this review show no significant differences in clinical outcomes between liberal and conventional oxygen therapy in adult ICU patients. As the burden of proof rests on the intervention, the absence of evidence for the superiority of liberal oxygen therapy means its benefit cannot be assumed.
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