ArticleClinical, cosmetic and investigational dermatology2025
The Association Between Anion Gap and Albumin-Corrected Anion Gap with Sun Sensitivity: A National Retrospective Cross-Sectional Study.
Article in Clinical, cosmetic and investigational dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Sun sensitivity is a significant factor influencing the risk of sunburn and skin cancer. Given that current assessments mainly depend on self-reported information, exploring objective biochemical indicators may provide complementary insights. The purpose of this research was to determine whether anion gap and albumin-corrected anion gap can function as objective and easily accessible biomarkers for sun sensitivity in US adults. Methods: We conducted a cross-sectional study utilizing data from the National Health and Nutrition Examination Survey collected between 2003-2006 and 2009-2018. Weighted logistic regression, restricted cubic splines, and subgroup analyses were conducted to examine the association between AG and ACAG and sun sensitivity. Results: The analysis was conducted on a total of 17,739 participants. We found a positive correlation between both AG and ACAG with increased sun sensitivity (AG: OR = 1.04, 95% CI = 1.01-1.07, P = 0.012; ACAG: OR = 1.04, 95% CI = 1.01-1.07, P = 0.004). It was observed that participants in the highest quartile (Q4) of AG and ACAG presented with heightened sensitivity to sunlight (AG: OR = 1.23, 95% CI = 1.02-1.50, P = 0.034; ACAG: OR = 1.29, 95% CI = 1.07-1.57, P = 0.01). Subgroup analyses indicated a consistent trend across various subgroups. Conclusion: Our study demonstrates that heightened levels of AG and ACAG are related to an elevated degree of sun sensitivity.
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