Altered Arginine Metabolism in Children Undergoing Fontan Palliation: A Prospective Cohort Study.
Benjamin S Frank, Sierra Niemiec, Ludmila Khailova, Christopher A Mancuso, Tanner Lehmann, Gareth J Morgan, Michael V DiMaria, Carmen C Sucharov, Jelena Klawitter, Jesse A Davidson
Article in Pulmonary circulation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Sierra NiemiecDepartment of Biostatistics and Informatics University of Colorado School of Public Health Aurora Colorado USA.
Ludmila KhailovaUniversity of Colorado Department of Pediatrics Section of Cardiology Aurora Colorado USA.
Christopher A MancusoDepartment of Biostatistics and Informatics University of Colorado School of Public Health Aurora Colorado USA.
Tanner LehmannUniversity of Colorado Department of Pediatrics Section of Cardiology Aurora Colorado USA.
Gareth J MorganUniversity of Colorado Department of Pediatrics Section of Cardiology Aurora Colorado USA.
Michael V DiMariaUniversity of Michigan Department of Pediatrics Section of Cardiology Ann Arbor Michigan USA.
Carmen C SucharovUniversity of Colorado Department of Medicine Section of Cardiology Aurora Colorado USA.
Jelena KlawitterUniversity of Colorado Department of Anesthesiology Aurora Colorado USA.
Jesse A DavidsonUniversity of Colorado Department of Pediatrics Section of Cardiology Aurora Colorado USA.
Funding
NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
Alkaline Phosphatase in Infant Cardiopulmonary Bypass: Kinetics and RelationshipK23HL123634 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI DAVIDSON, JESSE · 2014 to 2018
$826k
Pulmonary Vascular Development in Single Ventricle Heart Disease: A Longitudinal Biomarker ApproachK23HL163490 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Benjamin S Frank · 2023 to 2026
$745k
Systems biology of acute and chronic multi-organ failure in children with congenital heart diseaseK24HL167910 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Jesse Davidson · 2024 to 2026
Children with single ventricle heart disease (SVHD) demonstrate decreased arginine/NO metabolism following Stage 2 (Glenn) palliation, associated with poor postoperative outcomes. It is unknown if arginine dysregulation persists at Stage 3 (Fontan). The purpose of this study is to quantify circulating arginine metabolites in children undergoing Fontan palliation for SVHD to evaluate the relationship between metabolite concentrations and outcomes. Prospective cohort study of children undergoing Fontan operation (
Indexed as
ADMAcitrullinehypoplastic left heart syndromenitric oxidesingle ventricle
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Altered Arginine Metabolism in Children Undergoing Fontan Palliation: A Prospective Cohort Study. · full record | OpenQuestion