SynthesisFrontiers in neurology2025
Psychosocial stress and stroke risk: meta-analysis of observational studies.
Synthesis in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Psychosocial stress and risk of first-ever stroke: a systematic review and meta-analysis.BMC neurology · 2026Pooled it
- Meta-analysis of Early Risk Factors Associated with Cerebrovascular Diseases.Current neurovascular research · 2026Pooled it
- Temporal Increase in Strict Spontaneous Intracerebral Hemorrhage Admissions During the First March Following Direct Israel-Iran Hostilities: Preliminary Single-Center Findings from a Decade-Referenced Neuroscience Services Cohort.International journal of environmental research and public health · 2026Observational
- Higher allostatic load at hospitalization is linked to worse outcome 90 days after stroke.Frontiers in stroke · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Psychological stress has been increasingly recognized as a potential risk factor for stroke, but the strength and consistency of this association remained uncertain. This systematic review and meta-analysis aims to determine the overall association between broad psychological stress and broad stroke risk. Methodology: Systematic searches of PubMed, Scopus, Web of Science, and OVID databases from 1990 to March of 2025. These searches utilized a strategy combining subject headings and keywords related to psychosocial risk factors and stroke. Twenty-eight studies met inclusion criteria (23 prospective cohort and 5 case-control), comprising over 950,000 participants. We excluded studies involving participants with a history of depression. Stroke was broadly defined to include ischemic, hemorrhagic, subarachnoid, TIA, and unspecified subtypes. Results: Our meta-analysis of 23 prospective cohort studies found that individuals exposed to psychological stress had a 46% higher risk of experiencing stroke (HR = 1.46; 95% CI: 1.29-1.66; Conclusion: Psychological stress is significantly associated with an increased risk of fatal stroke, though publication bias and study heterogeneity highlight the need for cautious interpretation. Further research should aim to address methodological variability and selective reporting to refine our understanding of this relationship.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.