ReviewWorld journal of psychiatry2025
Unraveling the mysteries of schizophrenia: Insights into prefrontal cortex dysfunction and therapeutic implications.
Review in World journal of psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Apical integration theory provides a neural basis for understanding disorganization and consciousness in the schizophrenias.Current research in neurobiology · 2026Article
- The Impact of Humanistic Postoperative Care Integrated With the 6S Management Model on Postoperative Delirium and Psychiatric Symptoms in Patients With Schizophrenia Undergoing Surgery.Actas espanolas de psiquiatria · 2026Article
- The role of sensory experience in the maturation of prefrontal cortical circuits.Frontiers in neuroscience · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia is a multifaceted neurodevelopmental disorder characterized by hallucinations, delusions, cognitive deficits, and emotional dysregulation. The prefrontal cortex (PFC), essential for executive functions, working memory, and emotional regulation, is notably impaired in this condition. This review consolidates current insights into the role of PFC dysfunction in schizophrenia, with a focus on its implications for therapeutic strategies. The neuroanatomical and neurobiological foundations of PFC dysfunction are explored, emphasizing structural abnormalities, functional dysconnectivity, and microcircuit disruptions that contribute to cognitive deficits and impaired decision-making. Clinical implications are discussed, particularly the correlation between PFC dysfunction and the severity and progression of schizophrenia symptoms. Additionally, pharmacological and non-pharmacological approaches aimed at modulating PFC activity are reviewed as potential therapeutic options. In conclusion, a deeper understanding of PFC dysfunction is pivotal for developing targeted treatments, and ongoing research offers promising avenues for enhancing outcomes for individuals affected by this debilitating disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.