ArticleWorld journal of psychiatry2025
Sleep quality in bipolar disorder: A comparative study of treatment with lithium and valproic acid.
Article in World journal of psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The association between sleep spindles and cognitive performance in euthymic bipolar disorder.Translational psychiatry · 2026Article
- Lithium and valproic acid in bipolar disorder: Beyond mood stabilization, the overlooked role of sleep.World journal of psychiatry · 2025Article
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Authors and funding
3 authors.
Funding
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Abstract
backgroundSleep disturbances are a prominent feature of bipolar disorder (BD) and often persist even in remission, thereby contributing to poor clinical outcomes. Despite the widespread use of lithium and valproic acid as mood stabilizers, their effects on sleep quality have not been examined in adequate detail.
aimTo evaluate and compare the effects of lithium and valproic acid on sleep quality in BD patients under remission.
methodsA total of 130 patients meeting the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria for BD in remission were included in this cross-sectional study. The participants were receiving either lithium (
resultsBoth groups demonstrated poor sleep quality, with the mean PSQI scores above the clinical threshold of 5. Patients in the lithium group exhibited significantly better habitual sleep efficiency (lithium: 0.47 ± 0.65, valproic acid: 0.78 ± 0.87,
conclusionPatients in the lithium group showed significantly better habitual sleep efficiency and fewer sleep disturbances compared to those receiving valproic acid, although other sleep parameters did not differ. These findings suggest a potential advantage of lithium in certain aspects of sleep quality in BD patients under remission. Future studies using objective sleep measures and longitudinal designs are warranted to confirm these findings.
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