Evidence map›Paper›PMID 41281497›Full record

ArticleWorld journal of gastrointestinal oncology2025

Stromal secreted protein acidic and rich in cysteine expression: A potential target for improved prognosis in patients with pancreatic cancer.

Hye Yeon Yang, Jae Uk Chong, Mi Jang, Sung Hwan Lee, Ho Kyoung Hwang, Woo Jung Lee, Chang Moo Kang

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Article in World journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Hye Yeon YangDepartment of Surgery, Ajou University School of Medicine, Suwon 16499, South Korea.
Jae Uk ChongDepartment of Surgery, National Health Insurance Services Ilsan Hospital, Goyang 10444, South Korea.
Mi JangDepartment of Pathology, National Health Insurance Services Ilsan Hospital, Goyang 10444, South Korea.
Sung Hwan LeeDepartment of Surgery, CHA University, Bundang 13497, South Korea.
Ho Kyoung HwangDepartment of Surgery, Yonsei University College of Medicine, Seoul 03722, South Korea.
Woo Jung LeeDepartment of Surgery, Yonsei University College of Medicine, Seoul 03722, South Korea.
Chang Moo KangDepartment of Surgery, Yonsei University College of Medicine, Seoul 03722, South Korea. cmkang@yuhs.ac.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPancreatic cancer tissues mainly consist of fibrotic and dense stroma, which limits their therapeutic efficacy. The stromal fibroblasts of pancreatic tumors frequently express the secreted protein acidic and rich in cysteine (SPARC).

aimTo assess the impact of SPARC and its oncological relevance in patients undergoing pancreatic cancer resection.

methodsNinety-one pancreatic ductal adenocarcinoma specimens were obtained from patients with curative resection between January 2009 and December 2015 as a retrospective study. SPARC expression patterns were analyzed using immunohistochemistry. Oncological outcomes were analyzed based on SPARC expression patterns. Oncological outcomes, based on SPARC expression, were analyzed in The Cancer Genome Atlas-Pancreatic Adenocarcinoma cohort (retrieved from a public database).

resultsPatients with stromal SPARC expression (sSPARC+) had poorer overall survival than that in those without it (sSPARC-) (

conclusionAdjuvant chemotherapy improves survivals in sSPARC+ pancreatic cancer patients, indicating suggesting sSPARC expression as a prognostic biomarker and potential indicator for neoadjuvant treatment planning.

Indexed as

Pancreatic ductal adenocarcinomaSecreted protein acidic and rich in cysteineStromaSurvivalTumor microenvironment

Identifiers

PMID41281497
PMCPMC12635643

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