ReviewWorld journal of gastrointestinal oncology2025
Reassessing the role of lymph node dissection in pancreatic cancer surgery: Balancing oncologic control and immune function preservation.
Review in World journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
2 authors.
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Abstract
Lymph node dissection (lymphadenectomy) remains a critical component of pancreatic cancer surgery, contributing to accurate staging and guiding adjuvant therapy. The debate between standard and extended lymphadenectomy persists, with evidence showing no significant survival advantage of extended dissection over the standard approach. Extended lymphadenectomy, while increasing the number of lymph nodes retrieved, is associated with longer operative times, greater blood loss, and higher morbidity. More importantly, lymph nodes serve as critical immune hubs, and excessive removal may compromise systemic immune surveillance, which is vital in the context of emerging immunotherapies for pancreatic cancer. This minireview synthesizes the oncological and immunological perspectives on lymphadenectomy, advocating for a personalized approach to lymph node management in pancreatic cancer surgery, focusing on balancing oncologic outcomes with immune preservation.
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