ReviewOrthopaedic journal of sports medicine2025
Rehabilitation of the Knee After Autologous Matrix-Induced Chondrogenesis: A Systematic Review of Rehabilitation Protocols and Clinical and Radiological Outcomes.
Review in Orthopaedic journal of sports medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Background: Autologous matrix-induced chondrogenesis (AMIC) is an effective treatment for focal chondral knee lesions. Rehabilitation optimizes the environment for cartilage healing while avoiding deleterious effects to the repair site. Purpose: To evaluate rehabilitation protocols after AMIC and its effect on clinical and radiological outcomes. Study Design: Scoping review; Level of evidence, 4. Methods: Using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, the authors conducted a systematic search of the PubMed, Embase, Scopus, and Cochrane Library databases on April 30, 2025, using key search terms including "AMIC,""knee," and their synonyms. Outcomes assessed included the International Knee Documentation Committee (IKDC) score, visual analog scale (VAS) score, Lysholm score, and magnetic resonance imaging (MRI) findings. Descriptive synthesis of the data from 8 studies was conducted. Results: Eight studies were included, representing 258 patients (259 knees) with isolated AMIC. All chondral lesions were International Cartilage Regeneration & Joint Preservation Society grade 3 or 4 (mean defect size range, 2.6-3.7 cm Conclusion: This review demonstrated that rehabilitation protocols varied according to the location of the lesion, with a general trend of earlier weightbearing for patellofemoral lesions, in comparison with earlier ROM for condylar lesions. The postoperative clinical outcome and MRI findings are similar with both protocols, suggesting that this approach of customizing the ROM and weightbearing components in the rehabilitation protocol to the lesion site plays a role in the positive outcome.
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