ArticleJournal of medical biochemistry2025
Study on the prediction of prognosis of patients with acute liver failure treated with artificial liver by serum NLR and IL-6 levels.
Article in Journal of medical biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: To observe the relationship between the expression of serum interleukin-6 (IL-6) and neutrophil/lymphocyte ratio (NLR) and the prognosis of patients with acute liver failure (ALF) treated with artificial liver. Methods: 80 patients with ALF from January 2021 to October 2023 were included. All of them received artificial liver system treatment. All of the included subjects completed the effective follow-up for three months. The patients were followed up until April 30, 2023. According to the disease outcomes of patients after the end of follow-up, they were divided into a survival group and a death group. The serum IL-6 and NLR expressions of the two groups were compared, and the relationship between serum IL-6 and NLR expressions and the prognosis of patients with ALF treated with artificial liver was analysed. Results: The expression levels of serum IL-6 and NLR in the death group were higher (P<0.05). The high expressions of serum IL-6 and NLR might be a risk factor for the increased risk of death in patients with ALF after treatment (P<0.05). The receiver operating characteristic (ROC) curve indicated that the area under the curve (AUC) of fasting serum IL-6 and NLR expressions in patients with ALF predicting the prognosis of artificial liver treatment were 0.727 and 0.789. When the AUC of serum IL-6 combined with NLR predicted the prognosis of artificial liver treatment in patients with ALF, it was 0.889. Conclusions: The expression of serum IL-6 and NLR is correlated with the prognosis of patients with ALF treated with artificial liver.
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