Evidence map›Paper›PMID 41281238›Full record

ArticleArXiv2025

Recent Advances in Microfluidics and Bioelectronics for Three-Dimensional Organoid Interfaces.

Caroline Ferguson, Yan Li, Yi Zhang, Xueju Wang

Abstract readPreprint
PubMed Full text at PMC
In one paragraph

Article in ArXiv, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Caroline FergusonDepartment of Biomedical Engineering, College of Engineering, University of Connecticut, 260 Glenbrook Rd., Storrs, CT 06269, USA.
Yan LiDepartment of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Florida State University, 2525 Pottsdamer St., Tallahassee, FL 32310, USA.
Yi ZhangDepartment of Biomedical Engineering, College of Engineering, University of Connecticut, 260 Glenbrook Rd., Storrs, CT 06269, USA.
Xueju WangDepartment of Materials Science and Engineering, College of Engineering, University of Connecticut, 25 King Hill Rd., Storrs, CT 06269, USA.

Funding

A Wireless, Multimodal Neural Probe for Simultaneous Membrane-Free Neurochemical Sampling and NeuropharmacologyR01MH128721 · NIMH · UNIVERSITY OF CONNECTICUT STORRS · PI Yi Zhang · 2022 to 2026
$2.7M
Engineering Extracellular Vesicles of Human Brain Organoids for Stroke TherapyR01NS125016 · NINDS · FLORIDA STATE UNIVERSITY · PI Yan Li · 2022 to 2026
$1.8M
Multifunctional 3D Bioelectronic and Microfluidic Hybrid Systems for Online Monitoring, Regulation, and Vascularization of OrganoidsR21EB033495 · NIBIB · UNIVERSITY OF CONNECTICUT STORRS · PI WANG, XUEJU · 2022 to 2024
$644k
NIBIB NIH HHS R21 EB033495NIMH NIH HHS R01 MH128721NINDS NIH HHS R01 NS125016
6 · The paper itself

Abstract

Organoids offer a promising alternative in biomedical research and clinical medicine, with better feature recapitulation than 2D cultures. They also have more consistent responses with clinical results when compared to animal models. However, major challenges exist in the longevity of culture, the reproducibility of organoid properties, and the development of non-disruptive monitoring methods. Recent advances in materials and microfabrication methods, such as 3D printing and compressive buckling, have enabled three-dimensional (3D) interfaces of microfluidics and bioelectronics to manipulate and monitor these biological models in exciting ways. These advanced systems have great potential for applications in drug delivery, personalized medicine, and disease modelling. We conclude with important future considerations to generate longevity using further technological development in organoid and spheroid models.

Indexed as

3D Flexible Electronics3D MicrofluidicsOrganoidsOrgan-on-a-Chip

Identifiers

PMID41281238
PMCPMC12633148

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.