Evidence map›Paper›PMID 41281204›Full record

ArticleArXiv2025

ITRUSST Consensus on Biophysical Safety for Transcranial Ultrasound Stimulation.

Jean-François Aubry, David Attali, Mark E Schafer, Elsa Fouragnan, Charles F Caskey, Robert Chen, Ghazaleh Darmani, Ellen J Bubrick, Jérôme Sallet, Christopher R Butler and 8 more

Abstract readPreprint
PubMed Full text at PMC
In one paragraph

Article in ArXiv, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Jean-François AubryPhysics for Medicine Paris, Inserm U1273, ESPCI Paris, CNRS UMR8063, PSL University, Paris, France.
David AttaliPhysics for Medicine Paris, Inserm U1273, ESPCI Paris, CNRS UMR8063, PSL University, Paris, France.
Mark E SchaferRockefeller Neuroscience Institute, West Virginia University, Morgantown, West Virginia, USA.
Elsa FouragnanBrain Research Imaging Center, 7 Derriford Rd, Plymouth PL6 8BU; School of Psychology, Portland Square, Plymouth PL4 8AA, UK.
Charles F CaskeyVanderbilt University Institute of Imaging Sciences, VU Medical Center, Nashville, Tennessee, USA.
Robert ChenDivision of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Ghazaleh DarmaniKrembil Research Institute, University Health Network, Toronto, Ontario, Canada.
Ellen J BubrickBrigham and Women's Hospital, Harvard Medical School, Department of Neurology, 75 Francis St., Boston, MA, USA.
Jérôme SalletUniv Lyon, Université Lyon 1, Inserm, Stem Cell and Brain Research Institute U1208, Bron, France.
Christopher R ButlerDepartment of Brain Sciences, Imperial College London, London, W12 0BZ, UK.
Charlotte J StaggOxford Centre for Integrative Neuroimaging (OxCIN), FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, FMRIB Building, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK.
Miriam C Klein-FlüggeOxford Centre for Integrative Neuroimaging (OxCIN), Department of Experimental Psychology, University of Oxford, Oxford, OX1 3TA, UK.
Seung-Schik YooBrigham and Women's Hospital, Harvard Medical School, Department of Radiology, 75 Francis St., Boston, MA, USA.
Christy HollandDivision of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Brad TreebyDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK.
Eleanor MartinDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK.
Lennart VerhagenDonders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 GD Nijmegen, the Netherlands.
Kim Butts PaulyStanford University, Department of Radiology, Stanford CA 94305, USA.

Funding

Neurostimulation by Ultrasound: Physical, Biophysical, and Neural MechanismsR01NS112152 · NINDS · STANFORD UNIVERSITY · PI BACCUS, STEPHEN A, BUTTS-PAULY, KIM · 2020 to 2024
$4.9M
Translating an MR-guided focused ultrasound system for first-in-human precision neuromodulation of pain circuitsUG3NS135551 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CASKEY, CHARLES F, CHEN, LI MIN · 2023 to 2023
$4.4M
Step 1 in Designing Appropriate Shams and Controls in Human TUSR01MH131684 · NIMH · STANFORD UNIVERSITY · PI Kim Butts Pauly · 2023 to 2026
$2.6M
CRCNS: Crossbeam Transcranial Ultrasound Technology to Stimulate the Deep BrainR01EB032743 · NIBIB · STANFORD UNIVERSITY · PI BUTTS-PAULY, KIM · 2021 to 2023
$520k
NIBIB NIH HHS R01 EB032743NIMH NIH HHS R01 MH131684NINDS NIH HHS R01 NS112152NINDS NIH HHS UG3 NS135551Wellcome Trust
6 · The paper itself

Abstract

Transcranial ultrasound stimulation (TUS) is an emerging technology for non-invasive brain stimulation. The International Transcranial Ultrasonic Stimulation Safety and Standards consortium (ITRUSST) has established consensus on considerations for nonsignificant biophysical risk of TUS, drawing upon the literature and established regulations for biomedical devices. Here, we assume the application of TUS to individuals without contraindications, compromised thermoregulation, vascular vulnerabilities, or administered ultrasound contrast agents. In this context, we present a concise yet comprehensive set of levels for nonsignificant risks of TUS application. For mechanical effects, it is non-significant risk if the mechanical index (MI) or the mechanical index for transcranial application (MI

Identifiers

PMID41281204
PMCPMC12632700

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.