ArticleCureus2025
Primary Invasive Squamous Cell Carcinoma of the Vagina Presenting Three Decades After Total Hysterectomy for Benign Endometriosis: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
A 57-year-old woman (G2P2) with a history of total hysterectomy for endometriosis 30 years earlier, presented for a routine gynecological examination without complaints. Speculum examination revealed an erythematous, raised plaque at the right lateral fornix, 2-3 cm from the vaginal cuff. Pathology from the lesion demonstrated high-grade squamous intraepithelial lesion (HSIL) with HPV-16 positivity. Colposcopic biopsies from the 2, 7, 9, and 11 o'clock positions confirmed HSIL, with half of the samples suspicious for invasion. The patient underwent a partial vaginectomy, and histopathology revealed a moderately differentiated, HPV-associated invasive squamous cell carcinoma (SCC) with lymphovascular invasion. Margins were negative. This case demonstrates a unique case of primary vaginal cancer decades after hysterectomy for benign disease, underscoring the importance of continued gynecological surveillance in hysterectomy patients with previously benign findings.
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