ReviewCureus2025
Analgesic Efficacy of Magnesium in Lower Third Molar Surgery: A Systematic Review and Meta-Analysis.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Magnesium Sulfate as an Analgesic and Sedative-sparing Agent in Patients under Mechanical Ventilation: A Randomized, Double Blind Clinical Trial.Journal of research in pharmacy practice · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Achieving an optimal analgesic effect in patients undergoing lower third molar surgery from the administration of an inferior alveolar nerve block (IANB) remains unclear. Magnesium, a N-methyl-D-aspartate receptor antagonist, has shown positive results in reducing pain following surgery. This systematic review and meta-analysis aimed to study whether the use of magnesium is effective in lower third molar surgery. We conducted a comprehensive search on PubMed, Web of Science, Scopus, and the Cochrane Library from inception to September 2023 for randomized controlled trials (RCTs) assessing the use of magnesium as an oral tablet or as an adjuvant to IANB in patients undergoing lower third molar surgery. The primary outcome was the pain scores following surgery at 24 hours, 48 hours, and 72 hours. Secondary outcomes included the number of analgesics consumed and the frequency of patients receiving supplemental analgesia. We calculated the standardized mean difference (SMD) and risk ratio along with their 95% confidence intervals (CIs) using a random-effects model. All analyses were performed using STATA 19MP. We included five RCTs with 299 patients in the analysis. Oral magnesium was associated with lower pain scores at 24 hours, 48 hours, and 72 hours following the surgery, with the following values, respectively: SMD = -0.7, 95% CI = -1.03 to -0.37, p < 0.001; I² = 0%; -0.59, 95% CI = -0.92 to -0.26, p < 0.001; I² = 0%; and -0.68, 95% CI = -1.01 to -0.35, p < 0.001; I² = 0% compared to the control group, with no significant difference between the adjuvant magnesium and the control group. The oral use of magnesium resulted in a significant reduction in pain scores at 24 hours, 48 hours, and 72 hours post-procedure compared to the control group. Further long-term RCTs with standardized protocols are recommended to confirm the current findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.