ArticleCureus2025
Comparison of Procalcitonin, C-reactive Protein, and Interleukin-6 in the Postoperative Course After Lung Decortication Surgery: A Prospective Observational Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Immunopathogenesis of severe pneumonia in children with emphasis on CD4+ T cells, Tim-3 and cytokine-mediated immune dysregulation.Frontiers in medicine · 2026Review
- Effectiveness of free vastus lateralis musculocutaneous flap transplantation plus ultrasound-mediated transdermal Qianjin Weijing decoction for chronic empyema: a prospective, preference-based observational study.Frontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction Lung decortication is a surgical intervention performed to remove the fibrous pleural layer in conditions like pleural empyema or chronic pleuritis. Despite its therapeutic benefits, the postoperative period poses a high risk for complications such as infections and sepsis, which can significantly affect recovery. Biomarkers such as interleukin-6 (IL-6), C-reactive protein (CRP), and procalcitonin (PCT) are increasingly employed to aid early detection of such complications. Objectives To evaluate and compare the roles of IL-6, CRP, and PCT in detecting postoperative sepsis in patients undergoing lung decortication and to determine their clinical utility in guiding early management decisions. Methods This observational study was conducted in the Departments of Anaesthesiology and General Surgery, King George's Medical University, Lucknow. A total of 112 patients aged 18-65 years with clinically proven pleural empyema undergoing elective lung decortication were enrolled. Patients on preoperative anti-inflammatory or immunosuppressive drugs were excluded. Preoperatively and on postoperative days 1, 3, and 5, biomarkers were analyzed. Data analysis was performed using SPSS 26.0 (IBM Corp., Armonk, NY, US), applying t-tests, chi-square tests, and analysis of variance (ANOVA) with a significance threshold of p<0.05. Results Of 112 patients, 44 (39.3%) developed sepsis. Septic patients were older (mean age 40.84±14.08 years) than non-septic patients (mean age 28.09±8.00 years). PCT levels were significantly higher in septic patients across all time points (p<0.001), declining over time postoperatively. CRP levels were significantly elevated in septic patients on days 3 and 5. IL-6 and CRP showed limited but supportive diagnostic value. Mortality was higher in the septic group (6.8%), though not statistically significant. Conclusion Procalcitonin is the most reliable biomarker for the early detection and monitoring of postoperative sepsis following lung decortication. Combining PCT with CRP and IL-6 enhances diagnostic accuracy and informs timely therapeutic interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.