ArticleCureus2025
Optimising Gallium-68 (⁶⁸Ga) DOTATATE PET/CT Reconstruction in Neuroendocrine Tumours: A Paired Comparison of Penalised-Likelihood (BSREM/Q.Clear) and Ordered Subset Expectation Maximisation Algorithms.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective The aim was to determine whether "Q.Clear" (GE Healthcare, Bayesian Penalised Likelihood (BPL) reconstruction algorithm) of Gallium-68 (⁶⁸Ga) DOTATATE PET scans at different penalisation factors (β) could improve qualitative and quantitative image parameters compared with the standard Ordered Subsets Expectation Maximisation (OSEM), VPFX reconstruction. Methods Twenty-five PET/CT scans performed 60 minutes after injection of 110-224 MBq (activity 153 MBq/kg) of ⁶⁸Ga-DOTATATE on a GE Discovery 710 PET/CT scanner were reconstructed using VPFX (2 iterations, 24 subsets) and Q.Clear with β values ranging from 200-1200. A representative neuroendocrine tumour (NET) lesion and three reference regions (liver, spleen, and L3 bone marrow) were measured for standardised uptake values (SUVₘₐₓ/mean/peak/SD), signal-to-noise ratio (SNR = SUVₘₐₓ/liver SUV
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