ArticleCureus2025
Challenging the Skin Barrier: Intermediate-Term Success of Cryoablation for Superficial Invasive Mucinous Breast Cancer.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a case of an 88-year-old woman with significant comorbidities, diagnosed with a 2.2 cm invasive mucinous breast carcinoma located directly beneath the skin without an intervening fat plane. Given her high surgical risk, the patient underwent percutaneous cryoablation instead of wide excision surgery. Real-time ultrasound-guided hydrodissection was used to create a protective plane between the tumor and dermis, displacing the lesion 10 mm away from the skin. Controlled freeze-thaw cycles were performed using a 13G IceCure probe, ensuring complete ablation while minimizing skin injury. The procedure was well tolerated with no complications. Serial follow-up imaging for three years demonstrated a progressive reduction in lesion size, evolving into a subcentimeter scar-like region. The patient remained asymptomatic with no recurrence. This case underscores cryoablation as a viable, minimally invasive alternative to surgery, even for patients with challenging tumor locations, advocating for broader adoption in selected elderly or high-risk patients.
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