ArticleCureus2025
A Case Report of Longitudinal Extensive Transverse Myelitis: Ruling Out the Known Perpetrators.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Transverse myelitis (TM) is a rare, heterogeneous syndrome described as acute or subacute inflammation of the spinal cord, and longitudinally extensive transverse myelitis (LETM) is the term used to describe TM that is severe enough to produce T2-weighted high signal intensity on sagittal spinal magnetic resonance imaging (MRI) spanning three or more vertebral segments. We present a case of a 40-year-old African American woman who presented with a 2-day history of progressive bilateral hand weakness. Neurological examination revealed bilateral hand and wrist weakness, more pronounced on the left, with paresthesia from the mid-forearms down, not following a dermatomal pattern. Basic lab work was within normal limits. Autoimmune and infectious workup, including antineutrophil cytoplasmic antibodies (ANCA), thyroid peroxidase (TPO) antibodies, West Nile virus IgG/IgM, and rapid plasma reagin (RPR), was unremarkable. Erythrocyte sedimentation rate (ESR) was elevated at 46. Antinuclear antibodies (ANA) comprehensive plus profile was negative except for positive ribonucleoprotein (RNP) antibodies. Cerebrospinal fluid (CSF) analysis showed no oligoclonal bands. Computed tomography (CT) scan of the head and MRI of the brain were normal. MRI of the cervical and thoracic spine revealed patchy, irregular increased signal from C4-C7. The patient was diagnosed with LETM. She was started on IV methylprednisolone for three days, followed by tapering doses of oral prednisolone, and reported 80% resolution of paresthesia and improved upper limb motor function. At the two-week neurology follow-up, the patient reported near-complete recovery. Repeat cervical spine MRI showed marked improvement with no new enhancement. Despite being uncommon, LETM has devastating clinical outcomes, and many patients suffer from severe disability if treatment is delayed. In order to achieve maximally beneficial outcomes and, in some situations, initiation of the right treatment to avoid further bouts of central nervous system (CNS) inflammation, early identification and the etiology of LETM are crucial.
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