Evidence map›Paper›PMID 41280980›Full record

ArticleCureus2025

Antineutrophil Cytoplasmic Antibody (ANCA) Vasculitis, Fatigue, and Treatment With Avacopan: A Case Series.

Carl Schulze

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Carl SchulzeNephrology, University of California Los Angeles, Los Angeles, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This report describes three patients who developed marked somnolence and fatigue during treatment with avacopan for antineutrophil cytoplasmic antibody (ANCA) vasculitis. Though fatigue is a common symptom in ANCA vasculitis, each of these patients reported noticeable worsening of fatigue after starting avacopan, with improvement shortly after stopping the medication. All of them had a good response to treatment of their underlying vasculitis, and none of them had other clear causes of worsening fatigue.

Indexed as

anca-associated vasculitisavacopanchronic fatiguecomplement inhibitormpo-ancapauci-immune crescentic glomerulonephritissmall vessel vasculitis

Identifiers

PMID41280980
PMCPMC12631709

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.