Evidence map›Paper›PMID 41280920›Full record

ArticleFrontiers in immunology2025

Skewed pretransplant lymphocytes subpopulations correlate with opportunistic infection onset within the first two years following kidney transplantation.

Asma Beldi-Ferchiou, Florence Runyo, Florence Canoui-Poitrine, Bastien Peiffer, Benyamin Mattei Dediu, Cécile Maud Champy, Julie Oniusciuk, Giovanna Melica, Cédric Usureau, Nizar Joher and 4 more

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In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Asma Beldi-Ferchiou *Immunology Department, Henri-Mondor/Albert-Chenevier University Hospital, APHP, Créteil, France.
Florence Runyo *Nephrology and Renal Transplantation Department, Henri-Mondor/Albert-Chenevier University Hospital, Fédération Hospitalo-Universitaire TRUE (InnovaTive theRapy for immUne disordErs), APHP, Créteil, France.
Florence Canoui-PoitrineInstitut National de la Santé et de la Recherche Médicale (INSERM) U955, Institut Mondor de Recherche Biomédicale (IMRB), Université Paris-Est Créteil, Créteil, France.
Bastien PeifferAssistance Publique-Hôpitaux de Paris AP-HP, Hôpital Henri Mondor, DMU Medecine, Creteil, France.
Benyamin Mattei DediuPublic Health Department, Hôpitaux Universitaires Henri Mondor-Albert Chenevier, Assistance Publique-Hôpitaux de Paris (AP-HP), Créteil, France.
Cécile Maud ChampyUrology Department, Henri-Mondor/Albert-Chenevier University Hospital, APHP, Créteil, France.
Julie OniusciukNephrology and Renal Transplantation Department, Henri-Mondor/Albert-Chenevier University Hospital, Fédération Hospitalo-Universitaire TRUE (InnovaTive theRapy for immUne disordErs), APHP, Créteil, France.
Giovanna MelicaInfectious disease Department, Henri-Mondor/Albert-Chenevier University Hospital, APHP, Créteil, France.
Cédric UsureauLaboratoire d'Immunologie et Histocompatibilité, Hôpital Saint Louis, Paris, France.
Nizar JoherNephrology and Renal Transplantation Department, Henri-Mondor/Albert-Chenevier University Hospital, Fédération Hospitalo-Universitaire TRUE (InnovaTive theRapy for immUne disordErs), APHP, Créteil, France.
José CohenInstitut National de la Santé et de la Recherche Médicale (INSERM) U955, Institut Mondor de Recherche Biomédicale (IMRB), Université Paris-Est Créteil, Créteil, France.
Philippe GrimbertInstitut National de la Santé et de la Recherche Médicale (INSERM) U955, Institut Mondor de Recherche Biomédicale (IMRB), Université Paris-Est Créteil, Créteil, France.
Caroline PilonInstitut National de la Santé et de la Recherche Médicale (INSERM) U955, Institut Mondor de Recherche Biomédicale (IMRB), Université Paris-Est Créteil, Créteil, France.
Marie MatignonInstitut National de la Santé et de la Recherche Médicale (INSERM) U955, Institut Mondor de Recherche Biomédicale (IMRB), Université Paris-Est Créteil, Créteil, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: After kidney transplantation (KT), there is no reliable assessment of the immunosuppressive state. We analysed pre-KT T-, B- and NK-cell populations in relation to the occurrence of opportunistic infections (OI) or acute rejection (AR) after KT. Methods: We included 422 adult KT recipients from 01/2016 to 09/2020. Immune cells were analysed using flow cytometry in 283 recipients before KT in three groups: AR, OI or no event within 24 months after KT. Results: There were 49 recipients in the OI group, 44 in the AR group and 190 in the control group. Before KT, higher absolute counts and percentages of NK cells (p=0.001 and p=0.007 respectively), elevated absolute counts of plasmablasts and CD21 Conclusion: Our results suggest that higher levels of pretransplant NK cells and age-associated B cells are correlated with the occurrence of OI within two years after KT. This result may improve stratification of individualized infectious risk prior to KT.

Indexed as

Graft RejectionKidney TransplantationLymphocyte SubsetsOpportunistic InfectionsAdultAgedB-LymphocytesFemaleHumansKiller Cells, NaturalLymphocyte CountMaleMiddle Agedacute rejectionimmunomonitoringkidney transplantationNK cellsopportunistic infection

Identifiers

PMID41280920
PMCPMC12631297

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.