Evidence map›Paper›PMID 41280913›Full record

ArticleFrontiers in immunology2025

Carotenoid-based immune response in sea cucumbers relies on newly identified coelomocytes-the carotenocytes.

Noé Wambreuse, Estelle Bossiroy, Frank David, Céline Vanwinge, Laurence Fievez, Fabrice Bureau, Sylvain Gabriele, Tania Karasiewicz, Cyril Mascolo, Ruddy Wattiez and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Noé WambreuseBiology of Marine Organisms and Biomimetics Unit, Research Institute for Biosciences, University of Mons, Mons, Belgium.
Estelle BossiroyBiology of Marine Organisms and Biomimetics Unit, Research Institute for Biosciences, University of Mons, Mons, Belgium.
Frank DavidDirection Générale Déléguée à la Recherche, l'Expertise, la Valorisation et l'Enseignement (DGD REVE), Muséum National d'Histoire Naturelle (MNHN), Station Marine de Concarneau, Concarneau, France.
Céline VanwingeFlow Cytometry Platform, GIGA Research Institute, University of Liège, Liège, Belgium.
Laurence FievezLaboratory of Cellular and Molecular Immunology, GIGA Research Institute, University of Liège, Liège, Belgium.
Fabrice BureauLaboratory of Cellular and Molecular Immunology, GIGA Research Institute, University of Liège, Liège, Belgium.
Sylvain GabrieleSYMBIOSE Lab, Research Institute for Biosciences, CIRMAP, University of Mons, Mons, Belgium.
Tania KarasiewiczProteomics and Microbiology Unit, Research Institute for Biosciences, University of Mons, Mons, Belgium.
Cyril MascoloProteomics and Microbiology Unit, Research Institute for Biosciences, University of Mons, Mons, Belgium.
Ruddy WattiezProteomics and Microbiology Unit, Research Institute for Biosciences, University of Mons, Mons, Belgium.
Igor EeckhautBiology of Marine Organisms and Biomimetics Unit, Research Institute for Biosciences, University of Mons, Mons, Belgium.
Guillaume CaulierBiology of Marine Organisms and Biomimetics Unit, Research Institute for Biosciences, University of Mons, Mons, Belgium.
Jérôme DelroisseBiology of Marine Organisms and Biomimetics Unit, Research Institute for Biosciences, University of Mons, Mons, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sea cucumbers are marine deuterostomes possessing a complex innate immune system composed of a wide diversity of immune cells-coelomocytes-making them compelling models for exploring the evolution of immunity. This study investigates the functional specialisation of coelomocytes within the two main echinoderm body fluids, namely, the perivisceral fluid (PF) from the perivisceral cavity and the hydrovascular fluid (HF) from the hydrovascular-ambulacral system. Given their distribution restricted to the HF, haemocyte-like cells (HELs) are particularly investigated. In echinoderms, haemocytes have been described as reddish cells containing haemoglobin and thus presenting a function in oxygen transport. Using an integrative approach that combines cell morphological analyses, pigment profiling, and multi-omics technologies, we demonstrate in the sea cucumber

Indexed as

CarotenoidsHemocytesHolothuriaImmunity, InnateSea CucumbersAnimalsAntioxidantsReactive Oxygen SpeciesTranscriptomeAntioxidantsCarotenoidsReactive Oxygen SpeciesantioxidantdeuterostomeEchinodermatagene expressionhaemocytehydrovascular systemimmune cellreactive oxygen species

Identifiers

PMID41280913
PMCPMC12631484

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.