ArticleACS omega2025
Multiformity of a G/C Rich Segment at the Promoter-UTR Intersection of
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The structural architecture of G/C-rich segments at genomic locations has been a subject of curiosity and a hot research topic for many decades. An abundance of these G/C tracts at promoter location, 5'-UTR, and other genomic locations divulge their biological significance. Topological structural transition by G/C-rich tracts opens new avenues for designing specific molecules for therapeutic purposes. Though various biochemical and biophysical techniques have been employed to date to unravel the mysteries of these G/C-rich structural species, circular dichroism (CD) plays a substantial role in uncovering the topological intricacies of G/C-rich tetraplexes. Herein, we employed extensive CD studies for the revelation of the topological structural transition of the G-rich segment (RAP2C45) as well as its C-rich counterpart (RAP2C45C) located at the intersection of the promoter-UTR site of the
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