ArticleACS omega2025
Preparation of Rapid Self-Healing Hyaluronic Acid-Based Hydrogels via Dynamic Covalent Bonds for Drug Delivery Systems.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Multiple Dynamic Covalent Bond Crosslinked Ionic Liquids-Based Hydrogel with Stretchable, Rapid Self-Healing and Antibacterial Activity Properties.Gels (Basel, Switzerland) · 2026Article
- Hydrogel-Based Platforms for Wound Care: Integrated Strategies for Antimicrobial Delivery and Biofilm Management.Gels (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rapid self-healing hydrogels with superior mechanical properties are the most common carrier materials for drug release. In this study, hydrazide hyaluronic acid (DHA) was introduced into the reaction system of quaternary ammonium chitosan (QCS) and aldehyde hyaluronic acid (OHA). The hydrogels were synthesized by the "one-pot" method without additional toxic cross-linking agents. This approach enabled the formation of strong interactions through multiple dynamic covalent bonds (disulfide bond, imine bond, and acylhydrazone bond) and hydrogen bonds. The hydrogels demonstrated a rapid self-healing capability, achieving a 97% healing efficiency within just 10 min, and they also exhibited a compressive stress of 597 KPa. In addition, the hydrogels exhibited sensitive pH responsiveness and sustained drug release behavior. They also exhibited excellent cytocompatibility and antimicrobial properties. In conclusion, the hydrogel exhibits great potential in the biomedical field.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.