ArticleFood science & nutrition2025
Causal Relationship Between Gut Microbiota and Benign Prostatic Hyperplasia: A Two-Sample Mendelian Randomization Analyses, 16S rRNA Sequencing and Clinical Retrospective Study.
Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- The gut-prostate axis in benign prostatic diseases: Mechanistic pathways and therapeutic implications.iScience · 2026Review
- Review
- Microbial Genomic Consortia in Prostate Cancer: Mechanistic Signaling, the Gut-Prostate Axis, and Translational Perspectives.Cancers · 2026Review
- Causal Relationship Between Gut Microbiota and Benign Prostatic Hyperplasia: A Two-Sample Mendelian Randomization Analyses, 16S rRNA Sequencing and Clinical Retrospective Study.Food science & nutrition · 2025Article
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies suggest potential associations between gut microbiota (GM) and benign prostatic hyperplasia (BPH); however, the causal relationship remains uncertain. This study aims to explore the potential causal links between GM and BPH through Mendelian randomization (MR) analysis. A two-sample MR analysis was conducted using data from genome-wide association studies in accordance with the MR-STROBE statement. The inverse variance-weighted (IVW) method was utilized as the primary estimator. Robustness was evaluated by heterogeneity testing, horizontal pleiotropy assessment, and leave-one-out analyses. Fecal samples from BPH patients and healthy controls underwent 16S rRNA sequencing to evaluate their association with lower urinary tract symptom (LUTS) severity. IVW analyses associated
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