Evidence map›Paper›PMID 41280719›Full record

ArticleOrganelle (Tucson, Ariz.)2025

Targeting inflammasome pathway towards therapeutics of neurodegenerative diseases.

Wanli Smith, Mali Jiang, Jazlynn Meza, Gabriela Mercado

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organelle (Tucson, Ariz.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wanli SmithDepartment of Psychiatry, Division of Neurobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA 21287.
Mali JiangDepartment of Psychiatry, Division of Neurobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA 21287.
Jazlynn MezaDepartment of Psychiatry, Division of Neurobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA 21287.
Gabriela MercadoDepartment of Psychiatry, Division of Neurobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA 21287.

Funding

Advanced MRI Studies of Cerebrovascular and Lymphatic Abnormalities in LRRK2 mouse models of Parkinson's diseaseR01NS120879 · NINDS · JOHNS HOPKINS UNIVERSITY · PI HUA, JUN, SMITH, WANLI W · 2021 to 2025
$3.5M
LRRK2 and inflammasome pathway in Parkinson's diseaseR01NS119208 · NINDS · JOHNS HOPKINS UNIVERSITY · PI ROSS, CHRISTOPHER A, SMITH, WANLI W · 2021 to 2025
$3.2M
Huntingtin links inflammasome pathway in Huntington's disease PathogenesisR01NS129563 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Mali Jiang · 2024 to 2026
$1.7M
NINDS NIH HHS R01 NS119208NINDS NIH HHS R01 NS120879NINDS NIH HHS R01 NS129563
6 · The paper itself

Abstract

Inflammasome, an intracellular protein complex, is a crucial regulator of the innate immune response defending against harmful insults. Increasing evidence indicates that activation of inflammasome pathway in brain cells plays a significant pathological role in neurodegenerative diseases. Targeting this pathway offers a promising strategy for developing novel treatments. Here, we review the wide-ranging involvement of inflammasome activation in neurodegenerative diseases and highlight current therapeutic strategies targeting this critical pathway.

Indexed as

Caspase-1InflammasomeneurodegenerationneuroinflammationNLRP3

Identifiers

PMID41280719
PMCPMC12636706

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.