ArticleiScience2025
Association between environmental endocrine disruptors and autoimmune diseases: A systematic review and meta-analysis.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Machine learning and free energy clustering reveal PAH protein binding linked to AD risk.iScience · 2026Article
- The Cross-Knit Between Immune Cells and Thyroid Function in Autoimmune Thyroid Disorders: What We Can Learn from Inborn Errors of Immunity.Children (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environmental endocrine disruptors (EDCs) affect the immune system and influence the development of autoimmune diseases (ADs). However, a comprehensive summary of the relationship between EDCs and ADs has not been developed. Consequently, we conducted a systematic review and meta-analysis of previous observational studies examining the association between exposure to EDCs and AD outcomes. We searched relevant literature published from January 2008 to the present, which ultimately included 19 studies. The synthesis of evidence demonstrated a positive association between AD risk and exposure to major EDC classes such as bisphenols (strongest association: OR = 2.38, 95% CI: 1.27-4.45), organochlorine pesticides, phthalates, and polycyclic aromatic hydrocarbons. This trend was not observed for polychlorinated biphenyls. These findings position EDC exposure as a potential risk factor for ADs, yet the mechanistic pathways require elucidation. Future high-quality longitudinal and experimental studies are essential to confirm these relationships and explore the underlying biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.