Evidence map›Paper›PMID 41280690›Full record

ArticleiScience2025

Benzotriazole derivatives as alternate

Stefania Bova, Marialaura Pavone, Costanza Spadini, Nicolò Mezzasalma, Giacomo Quilici, Jole Maria Lucia D'Angelo, Francesca Malagutti, Omar De Bei, Chiara Spaggiari, Luca Ronda and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Stefania BovaDepartment of Medicine and Surgery, University of Parma, via Gramsci 14, 43125 Parma, Italy.
Marialaura PavoneDepartment of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.
Costanza SpadiniOperative Unit of Animals Infectious Diseases, Department of Veterinary Science, University of Parma, strada del Taglio 10, 43126 Parma, Italy.
Nicolò MezzasalmaOperative Unit of Animals Infectious Diseases, Department of Veterinary Science, University of Parma, strada del Taglio 10, 43126 Parma, Italy.
Giacomo QuiliciCentro di Servizi e Misure "G. Casnati", University of Parma, Parco Area delle Scienze 23/A, 43124 Parma, Italy.
Jole Maria Lucia D'AngeloDepartment of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.
Francesca MalaguttiDepartment of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.
Omar De BeiDepartment of Medicine and Surgery, University of Parma, via Gramsci 14, 43125 Parma, Italy.
Chiara SpaggiariDepartment of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.
Luca RondaDepartment of Medicine and Surgery, University of Parma, via Gramsci 14, 43125 Parma, Italy.
Marco PieroniDepartment of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.
Stefano BettatiDepartment of Medicine and Surgery, University of Parma, via Gramsci 14, 43125 Parma, Italy.
Clotilde Silvia CabassiOperative Unit of Animals Infectious Diseases, Department of Veterinary Science, University of Parma, strada del Taglio 10, 43126 Parma, Italy.
Barbara CampaniniDepartment of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.
Gabriele CostantinoDepartment of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.
Marialaura MarchettiDepartment of Medicine and Surgery, University of Parma, via Gramsci 14, 43125 Parma, Italy.
Giannamaria AnnunziatoDepartment of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cysteine biosynthetic pathway, unique to bacteria and absent in the human host, represents a relevant reservoir of potential antimicrobial targets. Cysteine, in fact, is involved in redox homeostasis and is prone to the production of reactive oxygen species, and altering its metabolic equilibrium provokes severe consequences on bacterial fitness and antibiotic response. Here, we developed a library of benzotriazole-derived compounds targeting

Indexed as

biological scienceschemistry

Identifiers

PMID41280690
PMCPMC12637403

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.