Evidence map›Paper›PMID 41280641›Full record

ArticleFrontiers in bioengineering and biotechnology2025

Inhibition of BRD4 activates the AKT-SIRT3 signaling pathway to suppress apoptosis and attenuate hyperoxia-induced lung injury.

Kangjie Qin, Jie Zheng, Yuting Zhang, Yiyu Wang, Han Qin, Qiuyu Dai, Xinxin Liu, Liting Cheng, Kun Yu, Miao Chen and 1 more

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In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kangjie Qin *Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Jie Zheng *Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Yuting ZhangDepartment of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Yiyu WangDepartment of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Han QinDepartment of Respiratory and Critical Care Medicine, Kweichow Moutai Hospital, Renhuai, Guizhou, China.
Qiuyu DaiZunyi Medical University, Zunyi, China.
Xinxin LiuDepartment of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Liting ChengDepartment of Critical Care Medicine, Kweichow Moutai Hospital, Renhuai, Guizhou, China.
Kun YuDepartment of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Miao ChenDepartment of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Song QinDepartment of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As a critical pulmonary complication in oxygen therapy, hyperoxia-induced lung injury (HILI) is featured with edema, alveolar wall thickening, and inflammatory cell infiltration. Bromodomain containing 4 (BRD4) has been documented as a vital regulator of apoptosis, inflammation, and oxidative stress under various pathological conditions. However, whether BRD4 plays a part in HILI has not yet been well investigated. The current investigation revealed a significant elevation of BRD4 expression in both

Indexed as

AEC-II cellsAktapoptosishyperoxia-induced lung injurysirt3

Identifiers

PMID41280641
PMCPMC12634603

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.