ArticleJournal of family medicine and primary care2025
Stool Gene-Xpert MTB/Rif test for the diagnosis of childhood pulmonary tuberculosis.
Article in Journal of family medicine and primary care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Diagnosing childhood pulmonary tuberculosis (PTB) is challenging due to nonspecific symptoms and difficulties in obtaining respiratory specimens. This study evaluates the diagnostic performance of the stool-based Xpert MTB/RIF assay as a noninvasive alternative compared to respiratory specimens in suspected cases. Material and Methods: This prospective, hospital-based study was carried out at a tertiary care centre, from November 2022 to October 2024. A total of 244 pediatric patients under 15 years of age with suspected PTB were included. Both stool and respiratory samples were collected and analyzed using the Xpert MTB/RIF assay and Mycobacteria growth indicator tube (MGIT) culture. Data analysis was performed using IBM SPSS software (version 22). Results: The Xpert MTB/RIF assay detected Conclusion: The stool Xpert MTB/RIF assay is a promising diagnostic tool for PTB in children, especially in resource-limited settings where respiratory sample collection is difficult. Although its sensitivity is lower compared to respiratory specimens, its high specificity makes it a reliable alternative. Future research should optimize stool sample processing and explore advanced diagnostic assays to improve sensitivity and accuracy.
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