Evidence map›Paper›PMID 41280565›Full record

ArticleAmerican journal of nuclear medicine and molecular imaging2025

Radiosynthesis and evaluation of a carbon-11 labeled PET ligand for imaging of O-GlcNAcase.

Yinlong Li, Xin Zhou, Zhendong Song, Taoqian Zhao, Jian Rong, Jiahui Chen, Chunyu Zhao, Qilong Hu, Xiaoyan Li, Chongjiao Li and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yinlong LiDepartment of Radiology and Imaging Sciences, Emory University Atlanta, GA 30322, The United States.
Xin ZhouDepartment of Radiology and Imaging Sciences, Emory University Atlanta, GA 30322, The United States.
Zhendong SongDepartment of Radiology and Imaging Sciences, Emory University Atlanta, GA 30322, The United States.
Taoqian ZhaoDepartment of Radiology and Imaging Sciences, Emory University Atlanta, GA 30322, The United States.
Jian RongDepartment of Radiology and Imaging Sciences, Emory University Atlanta, GA 30322, The United States.
Jiahui ChenDepartment of Radiology and Imaging Sciences, Emory University Atlanta, GA 30322, The United States.
Chunyu ZhaoDepartment of Radiology and Imaging Sciences, Emory University Atlanta, GA 30322, The United States.
Qilong HuDepartment of Radiology and Imaging Sciences, Emory University Atlanta, GA 30322, The United States.
Xiaoyan LiDepartment of Radiology and Imaging Sciences, Emory University Atlanta, GA 30322, The United States.
Chongjiao LiDepartment of Radiology and Imaging Sciences, Emory University Atlanta, GA 30322, The United States.
Zhenkun SunDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine Atlanta, GA 30322, The United States.
Yabiao GaoDepartment of Radiology and Imaging Sciences, Emory University Atlanta, GA 30322, The United States.
Jimmy S PatelDepartment of Radiology and Imaging Sciences, Emory University Atlanta, GA 30322, The United States.
Ahmad ChaudharyDepartment of Radiology and Imaging Sciences, Emory University Atlanta, GA 30322, The United States.
Hongjie YuanDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine Atlanta, GA 30322, The United States.
Steven H LiangDepartment of Radiology and Imaging Sciences, Emory University Atlanta, GA 30322, The United States.

Funding

micro-PET/CT system for preclinical molecular imagingS10OD034326 · OD · EMORY UNIVERSITY · PI LIANG, STEVEN H · 2024 to 2024
$600k
NIH HHS S10 OD034326
6 · The paper itself

Abstract

O-GlcNAcase (OGA) is a key enzyme involved in regulating the dynamic cycling of O-GlcNAc modifications on intracellular proteins. OGA has emerged as a promising therapeutic target for neurodegenerative diseases, including Alzheimer's disease. In this report, we present the radiosynthesis and preclinical assessment of a novel carbon-11 labeled positron emission tomography (PET) radioligand [

Indexed as

aminopyrimidine scaffoldO-GlcNAcasepositron emission tomographyradioligand

Identifiers

PMID41280565
PMCPMC12629900

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.