Delayed postoperative hemorrhage (DEPOH) in an Irish Wolfhound with the

Introduction: Delayed postoperative hemorrhage (DEPOH) is a life-threatening complication of major surgical procedures in Greyhounds affecting up to 26-30% of dogs. DEPOH has also been reported in Scottish Deerhounds, but it is unclear whether any other breeds are affected. A genetic variant (c.605 C > T) was recently discovered in the Methods: Case history and medical records from the affected dog were reviewed. Results: The reported case was a 2-year-old healthy female Irish Wolfhound who underwent ovariohysterectomy and prophylactic gastropexy procedures without complication. Two days later extensive bruising was noted on the ventral abdomen that spread to the torso by day 4 when the dog collapsed and died. Necropsy revealed extensive external and internal bruising with free and clotted blood in the abdomen. All ligatures were intact, and no sources of bleeding were identified. Subsequent genotyping indicated that this case was homozygous for the Discussion: These results suggest that DEPOH could occur in most, but not all sighthound breeds. Some non-sighthound breeds might also be susceptible.