Evidence map›Paper›PMID 41280335›Full record

ArticleTransplant international : official journal of the European Society for Organ Transplantation2025

Fixing a Mismatch: The Case for Age-Aligned Kidney Allocation.

Emmanouil Giorgakis, Sorabh Kapoor, Esteban Calderon, Melissa Chen, Kunal Kapoor, Alex Toledo, Chirag S Desai

Abstract read
In one paragraph

Article in Transplant international : official journal of the European Society for Organ Transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emmanouil GiorgakisDepartment of Surgery, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Sorabh KapoorDepartment of Surgery, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Esteban CalderonDepartment of Surgery, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Melissa ChenDepartment of Surgery, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Kunal KapoorDepartment of Surgery, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Alex ToledoDepartment of Surgery, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Chirag S DesaiDepartment of Surgery, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite recent advances, deceased donor kidney transplant allocation in the United States does not sufficiently account for the mismatch between donor and recipient age. This misalignment often leads to a suboptimal use of scarce resources. This viewpoint calls for restructuring of current kidney allocation strategies, advocating for a more intentional, age-matched approach that prioritizes better long-term quality kidneys for proportionally younger patients and encourages the use of older donor kidneys in similarly aged recipients. Drawing on the National Scientific Registry of Transplant Recipients data, clinical observations, and ethical reasoning, we argue that incorporating age in the organ allocation algorithms may improve both equity and utility in organ distribution. We also advocate for revision of the kidney donor risk calculators and placing a cap on the pre-emptive wait-time. Such realignments may reduce organ discard rates, enhance long-term graft utility, alleviate decision-making burdens on patients, and decrease the need for re-transplants on younger patients. To achieve this, recalibrations in allocation algorithms and reframing of what constitutes a "good" kidney are required. The goal is not to limit choice, but to structure a framework that maximizes benefit across populations while maintaining fairness towards a more sustainable model of transplant care.

Indexed as

Kidney TransplantationTissue and Organ ProcurementAgedAge FactorsAlgorithmsHumansMiddle AgedPatient SelectionResource AllocationTissue DonorsUnited StatesWaiting Listsage-matched allocationestimated post transplant survival scorekidney donor profile indexkidney transplant allocationolder donors

Identifiers

PMID41280335
PMCPMC12634456

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.