ArticleRSC advances2025
Auto-luminescence study of thermal unfolding of DNA G-quadruplexes.
Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
Funding
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Abstract
A new method for monitoring the unfolding of G-quadruplex DNA (G4) was proposed based on the native luminescence of the G4 system during its stepwise thermal denaturation. An antiparallel quadruplex formed by the Tel22 oligonucleotide (a fragment of human telomeric DNA) was used as a model in this study. Pre-folded G4 samples heated to various temperatures in the range of 50-90 °C were shock-frozen to trap the intermediates, and their low-temperature fluorescence and phosphorescence spectra were recorded. It was shown that effective unfolding of Tel22-G4 occurs in the region of 60-70 °C, and the process stops at temperatures above 80 °C. G4-associated fluorescence (
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