ArticleIBRO neuroscience reports2025
Restless legs syndrome and inflammatory bowel disease: A systematic review and meta-analysis.
Article in IBRO neuroscience reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Multidimensional iron dysmetabolism and gut-brain axis interactions in restless legs syndrome: from peripheral deficiency to central dysregulation.Frontiers in aging neuroscience · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and aim: Inflammatory bowel disease (IBD) is a prolonged inflammatory disorder that impacts the digestive system. To refer to one neurological complication, restless leg syndrome (RLS) manifests as movement impairment and leg restlessness. This situationprompted a need for a systematic review and meta-analysis to explore the correlation of these two diseases. Methods: A systematized search of relevant studies that were published up to September 2024 was conducted in PubMed, Scopus, Web of Science, and Google Scholar. The search strategy included keywords related to IBD, RLS, and their synonyms using MeSH terms. Data extraction and quality assessment were performed using a predefined protocol. All statistical analyses were performed using R software with the package "meta." Results: The pooled prevalence of RLS in IBD patients was 0.15 (0.08, 0.27), with a high heterogeneity indicated by I² = 98.8 % (p-value < 0.001). The subgroup analysis demonstrated notable variations depending on the geographic location. The prevalence of RLS in Crohn's disease (CD) was 0.17 (0.05, 0.45) with a high heterogeneity (I²: 98.9 %, P-value < 0.0001), and the prevalence of RLS in ulcerative colitis (UC) was 0.18 (0.06, 0.43) with a high heterogeneity (I²: 98.2 %, P-value < 0.0001). Positive associations have been found between CD and subsequent RLS in both sexes, as well as between UC and RLS, specifically in women. Conclusion: This analysis can provide compelling evidence to support any potential association between IBD and RLS, highlighting the importance of recognizing and addressing the potential comorbidity between these two conditions in clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.