Evidence map›Paper›PMID 41280126›Full record

ArticlebioRxiv : the preprint server for biology2025

Mechanism of single-strand annealing from native mass spectrometry and cryo-EM structures of RAD52 homolog Mgm101.

Carter T Wheat, Zihao Qi, Miqdad Hussain, Katerina Zakharova, Vicki H Wysocki, Charles E Bell

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Carter T WheatDepartment of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH 43210, USA.
Zihao QiDepartment of Chemistry and Biochemistry, and Native Mass Spectrometry Guided Structural Biology Center, The Ohio State University, Columbus, OH 43210, USA.
Miqdad HussainDepartment of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH 43210, USA.
Katerina ZakharovaDepartment of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH 43210, USA.
Vicki H WysockiDepartment of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0003-0495-2538
Charles E BellDepartment of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0001-6486-9408

Funding

ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
Native Mass Spectrometry Guided Structural Biology CenterRM1GM149374 · NIGMS · OHIO STATE UNIVERSITY · PI Vicki H. Wysocki · 2023 to 2026
$5.0M
Cellular, molecular, and biochemical sciences training grantT32GM141955 · NIGMS · OHIO STATE UNIVERSITY · PI Jane Elizabeth Jackman, JESSE J KWIEK · 2021 to 2026
$2.2M
NIGMS NIH HHS R01 GM129325NIGMS NIH HHS RM1 GM149374NIGMS NIH HHS T32 GM141955
6 · The paper itself

Abstract

RAD52, the primary single-strand annealing (SSA) protein in humans, forms undecameric rings that bind ssDNA within a narrow, positively-charged groove. Whether RAD52 anneals two complementary ssDNAs on the same ring in

Identifiers

PMID41280126
PMCPMC12633383

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.