Evidence map›Paper›PMID 41280111›Full record

ArticlebioRxiv : the preprint server for biology2025

A bioluminescence-based chemical screen identifies a bactericidal naphthalene scaffold targeting MmpL3 in

Samsher Singh, Ria Sorayah, Yushu Chen, Claire V Mulholland, Wassim Daher, Carmen J E Pee, Tan Ai Zhu Casandra, Denise Wee, Stefan H Oehlers, Kimberly A Kline and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Samsher SinghLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921, Singapore.ORCID 0000-0001-7075-931X
Ria SorayahLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921, Singapore.
Yushu ChenDepartment of Chemistry, National University of Singapore, Singapore, 117543, Singapore.
Claire V MulhollandDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Wassim DaherCentre National de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier, Montpellier, France.
Carmen J E PeeLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921, Singapore.
Tan Ai Zhu CasandraSingapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore, 637551, Singapore.
Denise WeeA*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos #05-13, Singapore 138648, Singapore.
Stefan H OehlersLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921, Singapore.
Kimberly A KlineDepartment of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland.
Shu Sin ChngDepartment of Chemistry, National University of Singapore, Singapore, 117543, Singapore.
Michael BerneyDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.
Laurent KremerCentre National de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier, Montpellier, France.
Garrett MoraskiDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, Montana, USA.
Kevin PetheLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921, Singapore.

Funding

Research Core (Developmental Research Project Program)P20GM103474 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Ann Therese Bertagnolli · 2012 to 2026
$60.0M
Design, Syntheses and Studies of Novel Antituberculosis AgentsR37AI054193 · NIAID · UNIVERSITY OF NOTRE DAME · PI MILLER, MARVIN J · 2016 to 2025
$5.2M
Identification of new inhibitors of essential functions in M. tuberculosis by high-throughput metabolic profilingR01AI173328 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Michael Berney · 2023 to 2026
$2.6M
The PDIM paradox of M. tuberculosisR01AI175972 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Michael Berney · 2023 to 2026
$2.0M
Acquisition of a 600 MHz NMR cryoprobe and 600 MHz spectrometer console upgradeS10RR026659 · NCRR · MONTANA STATE UNIVERSITY - BOZEMAN · PI COPIE, VALERIE · 2011 to 2011
$600k
Ultra Performance Liquid Chromatography Tandem Mass Spectrometer for MetabolomicsS10OD028650 · OD · MONTANA STATE UNIVERSITY - BOZEMAN · PI BOTHNER, BRIAN P · 2020 to 2020
$599k
NCRR NIH HHS S10 RR026659NIAID NIH HHS R01 AI173328NIAID NIH HHS R01 AI175972NIAID NIH HHS R37 AI054193NIGMS NIH HHS P20 GM103474NIH HHS S10 OD028650
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID41280111
PMCPMC12633243

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.