ArticlebioRxiv : the preprint server for biology2025
Altair-LSFM A High-Resolution, Easy-to-Build Light-Sheet Microscope for Sub-Cellular Imaging.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Although several open-source, easy-to-assemble light-sheet microscope platforms already exist-such as mesoSPIM, OpenSPIM, and OpenSpin-they are optimized for imaging large specimens and lack the resolution required to visualize sub-cellular features, such as organelles or cytoskeletal architectures. In contrast, Latice Light-Sheet Microscopy (LLSM) achieves the resolution necessary to resolve such fine structures but, in its open-source implementation, can be alignment- and maintenance-intensive, often requiring specialist expertise. To address this gap, we developed Altair-LSFM, a high-resolution, open-source, sample-scanning light-sheet microscope specifically designed for sub-cellular imaging. By optimizing the optical pathway in silico, we created a custom baseplate that greatly simplifies alignment and assembly. The system integrates streamlined optoelectronics and optomechanics with seamless operation through our open-source software,
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