Evidence map›Paper›PMID 41280100›Full record

ArticlebioRxiv : the preprint server for biology2025

Buffering of genetic defects in animal development by regeneration programs.

Kazunori Ando, Sushant Bangru, John Welsby, John D Thompson, Kenneth D Poss

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Kazunori AndoMorgridge Institute for Research, 330 N Orchard Street, Madison, WI 53715, USA.
Sushant BangruMorgridge Institute for Research, 330 N Orchard Street, Madison, WI 53715, USA.
John WelsbyDuke University School of Medicine, Department of Cell Biology, Durham, NC 27710, USA.
John D ThompsonDuke University School of Medicine, Department of Cell Biology, Durham, NC 27710, USA.ORCID 0000-0003-0248-8743
Kenneth D PossMorgridge Institute for Research, 330 N Orchard Street, Madison, WI 53715, USA.ORCID 0000-0002-6743-5709

Funding

Regulation of Appendage Regeneration in ZebrafishR01HD105033 · NICHD · MORGRIDGE INSTITUTE FOR RESEARCH, INC. · PI POSS, KENNETH D · 2021 to 2025
$2.0M
NICHD NIH HHS R01 HD105033
6 · The paper itself

Abstract

Regeneration programs enable animals to restore damaged or lost tissues, and the range of stimuli for these programs is incompletely understood. Here, we used zebrafish, a vertebrate species with exceptional regenerative capacity, to identify chemically induced mutations that alter regeneration-associated gene activation. Transgenic zebrafish with a permissive promoter and EGFP cassette inserted in the vicinity of the pro-regenerative factor gene

Indexed as

developmental defectsfgf20afin regenerationfras1regeneration programsskin disorderzebrafish

Identifiers

PMID41280100
PMCPMC12633463

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.