Evidence map›Paper›PMID 41280088›Full record

ArticlebioRxiv : the preprint server for biology2025

Host cyclophilin-mediated maturation of an obligate intracellular bacterial surface virulence factor.

Brandon Sit, Allen G Sanderlin, Clara Y Zhu, Lauren E Bird, John G Doench, Rebecca L Lamason

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Brandon SitDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0003-2378-3039
Allen G SanderlinDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-9230-9157
Clara Y ZhuDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0009-0000-0033-6477
Lauren E BirdDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0001-7082-3115
John G DoenchGenetic Perturbation Platform, Broad Institute, Cambridge, MA, USA.ORCID 0000-0002-3707-9889
Rebecca L LamasonDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-2762-7917

Funding

Mechanisms of SFG Rickettsia-Host InteractionsR01AI155489 · NIAID · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI REBECCA L LAMASON · 2021 to 2026
$3.7M
Microbial Control of Host Intercellular CommunicationR01GM141025 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LAMASON, REBECCA L · 2022 to 2025
$1.2M
Investigating genes of unknown function required for Rickettsia parkeri infectionF32AI172121 · NIAID · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SIT, BRANDON YIU CHUNG · 2022 to 2024
$210k
NIAID NIH HHS F32 AI172121NIAID NIH HHS R01 AI155489NIGMS NIH HHS R01 GM141025
6 · The paper itself

Abstract

Obligate intracellular bacterial pathogens cannot grow extracellularly, a trait that renders them highly understudied, but also endows them with unexpected host dependencies. Here, using the emerging obligate intracellular tickborne pathogen

Identifiers

PMID41280088
PMCPMC12636401

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.