Evidence map›Paper›PMID 41280075›Full record

ArticlebioRxiv : the preprint server for biology2025

mRNA delivery of genetically encoded mosaic-8 pan-sarbecovirus RBD vaccines.

Alexander A Cohen, Jennifer R Keeffe, Lusineh Manasyan, Indeever Madireddy, Ange-Célia I Priso Fils, Kim-Marie A Dam, Haley E Stober, Rory A Hills, Woohyun J Moon, Paulo J C Lin and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Alexander A CohenDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.ORCID 0000-0002-2818-656X
Jennifer R KeeffeDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.ORCID 0000-0002-5317-6398
Lusineh ManasyanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Indeever MadireddyDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.ORCID 0000-0002-8460-8579
Ange-Célia I Priso FilsDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.ORCID 0009-0001-3506-1079
Kim-Marie A DamGladstone Institutes, San Francisco, CA 94158, USA.ORCID 0000-0002-1416-4757
Haley E StoberGladstone Institutes, San Francisco, CA 94158, USA.
Rory A HillsDepartment of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK.ORCID 0000-0002-5698-9538
Woohyun J MoonAcuitas Therapeutics, Vancouver, BC, V6T 1Z3, Canada.ORCID 0009-0001-1395-823X
Paulo J C LinAcuitas Therapeutics, Vancouver, BC, V6T 1Z3, Canada.
Mark R HowarthDepartment of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK.ORCID 0000-0001-8870-7147
Magnus A G HoffmannGladstone Institutes, San Francisco, CA 94158, USA.ORCID 0000-0003-4923-9568
Pamela J BjorkmanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.ORCID 0000-0002-2277-3990

Funding

The longevity and nature of the anti-SARS-CoV-2 cellular and humoral immune responsesP01AI165075 · NIAID · ROCKEFELLER UNIVERSITY · PI BJORKMAN, PAMELA J · 2022 to 2023
$10.7M
Self-Assembling Spike-EBR Nanoparticles as a Vaccine Platform Technology Against SARS-CoV-2 and Future Pandemic Coronaviruses.DP5OD033362 · OD · J. DAVID GLADSTONE INSTITUTES · PI HOFFMANN, MAGNUS ADRIAN GERO · 2022 to 2025
$2.3M
Determining the role of antibody epitope specificity in regulating Fc effector functionsK99AI185267 · NIAID · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI Alexander A Cohen · 2025 to 2026
$257k
NIAID NIH HHS K99 AI185267NIAID NIH HHS P01 AI165075NIH HHS DP5 OD033362Wellcome Trust
6 · The paper itself

Abstract

Global health remains threatened by spillovers of zoonotic SARS-like betacoronaviruses (sarbecoviruses) that could be mitigated by a pan-sarbecovirus vaccine

Indexed as

Deep mutational scanningepitope mappingmRNA and protein nanoparticle vaccinespandemic preparednesspan-sarbecovirus vaccineSySPEM (systems serology-polyclonal epitope mapping)systems serology

Identifiers

PMID41280075
PMCPMC12633426

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.