Evidence map›Paper›PMID 41280056›Full record

ArticlebioRxiv : the preprint server for biology2025

Efficient

Sean McNeme, Anil Kumar, Yun Young Yim, Brandon W Hughes, Corey St Romain, Yi Li, Ashwani Kumar, Qichao Bao, Molly Estill, Shanghua Fan and 11 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Funding

Small molecule modulators of ΔFosB FunctionR01DA040621 · NIDA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI NESTLER, ERIC J., ROBISON, ALFRED J · 2016 to 2025
$7.1M
Projection-specific gene expression in resilience to chronic stressR01MH111604 · NIMH · MICHIGAN STATE UNIVERSITY · PI Michelle Suzanne Mazei-Robison, ALFRED J ROBISON · 2016 to 2026
$4.9M
Training Program in Substance Use DisordersT32DA053558 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Paul J. Kenny · 2021 to 2026
$2.6M
NIDA NIH HHS R01 DA040621NIDA NIH HHS T32 DA053558NIMH NIH HHS R01 MH111604
6 · The paper itself

Abstract

ΔFOSB, an unusually stable member of the AP1 family of transcription factors, mediates long-term maladaptations that play a key role in the pathogenesis of drug addiction, cognitive decline, dyskinesias, and several other chronic neurological and psychiatric conditions. We have recently identified that 2-phenoxybenzenesulfonic acid-containing compounds disrupt the binding of ΔFOSB to DNA IN BRIEF: We demonstrate the creation of a highly effective inhibitor, YL0441, of ΔFOSB, an AP1 transcription factor, which decreases the number of ΔFOSB-bound sites to genomic DNA by ∼94% upon

Identifiers

PMID41280056
PMCPMC12633346

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.