Evidence map›Paper›PMID 41280048›Full record

ArticlebioRxiv : the preprint server for biology2025

Structural mechanism of lipid modulation of pentameric ligand-gated ion channel activity.

Brandon K Tan, Hanrui Xu, Jesse W Sandberg, Grace Brannigan, Wayland W L Cheng

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Brandon K TanDepartment of Anesthesiology, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0002-7291-793X
Hanrui XuDepartment of Anesthesiology, Washington University School of Medicine, Saint Louis, MO, USA.
Jesse W SandbergCenter for Computational and Integrative Biology, Rutgers University, Camden, NJ, USA.ORCID 0000-0001-7466-8466
Grace BranniganCenter for Computational and Integrative Biology, Rutgers University, Camden, NJ, USA.ORCID 0000-0001-8949-2694
Wayland W L ChengDepartment of Anesthesiology, Washington University School of Medicine, Saint Louis, MO, USA.ORCID 0000-0002-9529-9820

Funding

Lipid Modulation of Ligand-Gated Ion ChannelsR35GM137957 · NIGMS · WASHINGTON UNIVERSITY · PI Wayland Wing-Lun Cheng · 2020 to 2026
$2.9M
NIGMS NIH HHS R35 GM137957
6 · The paper itself

Abstract

Pentameric ligand-gated ion channels (pLGICs) are sensitive to the lipid environment. However, the structural mechanism of how specific lipids support the agonist response of any pLGIC is poorly understood. Using the model pLGIC, ELIC (

Identifiers

PMID41280048
PMCPMC12632492

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.