ArticlebioRxiv : the preprint server for biology2025
tRNA Modification Landscapes in Streptococci: Shared Losses and Clade-Specific Adaptations.
Ho-Ching Tiffany Tsui, Chi-Kong Chan, Yifeng Yuan, Roba Elias, Jingjing Sun, Virginie Marchand, Marshall Jaroch, Guangxin Sun, Irfan Manzoor, Ana Kutchuashvili and 8 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
18 authors.
Ho-Ching Tiffany TsuiDepartment of Biology, Indiana University Bloomington, Bloomington, Indiana, USA.ORCID 0000-0003-0849-874X Chi-Kong ChanDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.ORCID 0000-0001-7963-8725 Yifeng YuanDepartment of Microbiology and Cell Science, University of Florida, Gainesville, Florida, USA.
Roba EliasDepartment of Microbiology and Cell Science, University of Florida, Gainesville, Florida, USA.
Jingjing SunDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Virginie MarchandUniversité de Lorraine, SMP IBSLor, EpiRNA-Seq core facility, F-54000 Nancy, France.ORCID 0000-0002-8537-1139 Marshall JarochDepartment of Microbiology and Cell Science, University of Florida, Gainesville, Florida, USA.
Guangxin SunDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Ana KutchuashviliDepartment of Chemistry, San Diego State University, California, USA.
Grazyna LeszczynskaInstitute of Organic Chemistry, Lodz University of Technology, Łódź, Poland.
Kinda SeatonDepartment of Microbiology and Cell Science, University of Florida, Gainesville, Florida, USA.
Kelly C RiceDepartment of Microbiology and Cell Science, University of Florida, Gainesville, Florida, USA.ORCID 0000-0003-1335-4409 Peter C DedonDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.ORCID 0000-0003-0011-3067 Valérie de Crécy-LagardDepartment of Microbiology and Cell Science, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-9955-3785 Funding
Synthesis and function of Queuosine in BacteriaR01GM070641 · NIGMS · UNIVERSITY OF FLORIDA · PI DE CRECY-LAGARD, VALERIE A · 2006 to 2023
$5.3MNew Regulatory Interactions and Circuits that Mediate the Dynamics, Homeostasis, and Stress Responses of Peptidoglycan Synthesis in the Superbug Streptococcus pneumoniaeR35GM131767 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI MALCOLM E. WINKLER · 2019 to 2026
$4.8MTranslational regulation in exposure biology: Xenobiotic-induced reprograming oftRNA modifications and selective translation of codon-biased response genes in rat and humanmodelsR01ES026856 · NIEHS · SUNY POLYTECHNIC INSTITUTE · PI Thomas J Begley, Peter C Dedon · 2016 to 2026
$3.9MRNA modification: Structure and MechanismR01GM110588 · NIGMS · WESTERN UNIVERSITY OF HEALTH SCIENCES · PI SWAIRJO, MANAL A · 2014 to 2024
$3.9MLinking gene and function through comparative genomic and experimental approachesR35GM156215 · NIGMS · UNIVERSITY OF FLORIDA · PI Valerie A de Crecy-Lagard · 2025 to 2026
$1.3MNIEHS NIH HHS R01 ES026856NIGMS NIH HHS R01 GM070641NIGMS NIH HHS R01 GM110588NIGMS NIH HHS R35 GM131767NIGMS NIH HHS R35 GM156215
6 · The paper itselfAbstract
tRNA modifications are central to bacterial translational control. Here, we integrated genetics, mass spectrometry, epitranscriptomics, and comparative genomics to map the tRNA modification genes of the Gram-positive pathogens
Indexed as
DihydrouridinepseudogeneQueuosinet6AtRNA modificationTsaE
Identifiers
PMID41280037
PMCPMC12632869
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