Evidence map›Paper›PMID 41280018›Full record

ArticlebioRxiv : the preprint server for biology2025

Optogenetic control of PLC-γ1 activity polarizes cell motility.

Ravikanth Appalabhotla, Priscila F Siesser, Harrison Truscott, Nicole Hajicek, John Sondek, James E Bear, Jason M Haugh

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Ravikanth AppalabhotlaDepartment of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina.
Priscila F SiesserDepartment of Cell Biology and Physiology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
Harrison TruscottDepartment of Cell Biology and Physiology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
Nicole HajicekDepartment of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
John SondekDepartment of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
James E BearDepartment of Cell Biology and Physiology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
Jason M HaughDepartment of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina.ORCID 0000-0002-2476-4027

Funding

Systematic Analysis of the Actin Cytoskeleton and Directed Cell MigrationR35GM130312 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JAMES E BEAR · 2019 to 2026
$4.8M
Phospholipase C IsozymesR35GM149299 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JOHN E SONDEK · 2023 to 2026
$1.7M
Multi-cue Guidance of Mesenchymal Cell MigrationR01GM141691 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI HAUGH, JASON M. · 2021 to 2024
$1.2M
NIGMS NIH HHS R01 GM141691NIGMS NIH HHS R35 GM130312NIGMS NIH HHS R35 GM149299
6 · The paper itself

Abstract

Phospholipase C-γ1 (PLC-γ1) signaling is required for mesenchymal chemotaxis, but is it sufficient to bias motility? PLC-γ1 enzyme activity is basally autoinhibited, and light-controlled membrane recruitment of wild-type (WT) PLC-γ1 (OptoPLC-γ1) in

Identifiers

PMID41280018
PMCPMC12632280

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.