Evidence map›Paper›PMID 41280010›Full record

ArticlebioRxiv : the preprint server for biology2025

Antibody-mediated feedback modulates interclonal competition in the germinal center.

Alexandru Barbulescu, Jana Bilanovic, Tom Langelaar, A Katharina Teetz, Linas Urnavicius, Alvaro Hobbs, Jin-Jie Shen, Nadine H Abrahamse, Renan V H de Carvalho, Luka Mesin and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Alexandru BarbulescuLaboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.
Jana BilanovicLaboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.
Tom LangelaarLaboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.
A Katharina TeetzLaboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.
Linas UrnaviciusLaboratory of Chemistry and Cell Biology, The Rockefeller University, New York, NY, USA.
Alvaro HobbsLaboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.
Jin-Jie ShenLaboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.
Nadine H AbrahamseLaboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.
Renan V H de CarvalhoLaboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.
Luka MesinLaboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.
Cecilio L FerreiraLaboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.
Juliana BortolattoLaboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.
Gabriel D VictoraLaboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.ORCID 0000-0001-8807-348X

Funding

Weill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1M
Dynamics of Antigen-Driven Selection in Germinal CentersR01AI119006 · NIAID · ROCKEFELLER UNIVERSITY · PI Gabriel D Victora · 2017 to 2026
$5.7M
Defining the role of T cell help in germinal centers by intercellular enzymatic labelingR01AI173086 · NIAID · ROCKEFELLER UNIVERSITY · PI Gabriel D Victora · 2022 to 2026
$4.0M
Inferring the rules of antibody evolution using replicated germinal centersR01AI180451 · NIAID · ROCKEFELLER UNIVERSITY · PI Gabriel D Victora · 2024 to 2026
$2.4M
Investigating the Effect of Antibody Mediated Feedback on B Cell Clonal SelectionF30AI157448 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI BARBULESCU, ALEXANDRU · 2021 to 2024
$209k
Uncovering immune network principles driving humoral immunity in inflammatory conditionsF99CA305580 · NCI · ROCKEFELLER UNIVERSITY · PI Jana Bilanovic · 2025 to 2026
$101k
NCI NIH HHS F99 CA305580NIAID NIH HHS F30 AI157448NIAID NIH HHS R01 AI119006NIAID NIH HHS R01 AI173086NIAID NIH HHS R01 AI180451NIGMS NIH HHS T32 GM007739Wellcome Trust
6 · The paper itself

Abstract

Serum antibodies from prior immune responses regulate B cell activation and germinal center (GC) access upon recall immunization. However, how antibodies produced by an ongoing immune response influence the outcomes of contemporaneous GCs is less clear. To explore this, we developed mouse models enabling the targeted ablation of plasma cells and antibodies produced by an immune response of interest, without affecting those produced homeostatically or by prior antigen encounters. Our findings show that, whereas antibody-mediated feedback is not required for affinity maturation, it can influence competition between B cells with different epitope specificities, specifically by reducing the abundance of clones that recognize the same epitopes as circulating antibodies. This modality of feedback represents a mechanism by which antibody responses can influence epitope specificity in ongoing GCs. These findings may therefore have implications for vaccination strategies aimed at steering clonal selection towards desired epitopes on complex antigens.

Identifiers

PMID41280010
PMCPMC12637549

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.